MUSE

IBS : International

Séminaire

The Key Initiative Interdisciplinary Blood Science initiated by I-SITE MUSE had the pleasure to organize, on Friday April 21th 2022, the webinar of Dr Laurent Yvernogeau, CNRS Researcher at Developmental Biology Laboratory. He gave a talk about “Dissecting the first steps leading to hematopoietic stem cell emergence: lessons from the chicken embryo« .

The Key Initiative Interdisciplinary Blood Science initiated by I-SITE MUSE had the pleasure to organize the webinar of Professor Marieke von Lindern, Head of the Hematopoiesis at Sanquin Institute. She will be talking about “BLOOD 2.0 Cultured red blood cells for transfusion purposes” on Friday, July 9th, at 3 pm (Paris time).

The Key Initiative Interdisciplinary Blood Science initiated by I-SITE MUSE had the pleasure to organize, on friday May 7th, a webinar where Dr Narla Mohandas, Vice President for Research of New York Blood Center. Dr Narla talked about “Red Cells : Past, Present and Future”. This very interesting webinar has been an international success which gathered 240 scientists.

Scientifiques invités

Après avoir participé à un webinaire, le 7 mai 2021, le Dr Narla Mohandas, Vice-Président du New York Blood Center et mondialement reconnu pour la qualité de ses recherches, a été invité par la KIM à effectuer un séjour de recherche à Montpellier du 3 octobre au 3 novembre 2021.

Dans ce cadre, il animera deux séminaires exceptionnels qui porteront sur notre compréhension du fonctionnement des globules rouges dans la santé et la maladie, et de la manière dont ces cellules essentielles sont produites par le corps humain.

Mardi 19 octobre 2021  : Red Cell Function in Health and Disease

Mardi 26 octobre 2021 : Stem Cells to Red Cells

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Le docteur Mohandas Narla, Vice-Président du New York Blood Center aux Etats-Unis, a reçu le prestigieux prix Wallace H. Coulter pour l’ensemble de ses réalisations et leur impact en hématologie, lors de la 62e réunion annuelle All-Virtual de l’American Hematology Society.

Conférences internationales

Une session de l’école internationale d’Hémophysique, qui fait le point, tous les 2 ans, sur les avancées en matière d’analyse et de compréhension de la physique des écoulements sanguins, a été organisée en octobre 2021.

Une conférence internationale intitulée« Blood-Tissue Interfaces » se déroulera à Montpellier, du 2 au 4 octobre 2022.

First International “Blood Tissue Interfaces” conference October, 3-4, 2022 Montpellier

The First International “Blood Tissue Interfaces” Conference took place  in Montpellier – Planet Ocean – (France), on October, 3-4, 2022

This interdisciplinary intended for anyone who would like to learn about the state-of-the-art in this rich field as well as for experts to engage in fruitful discussions and create new synergies in academia and with the industrial communities. Lectures have been given by highly skilled invited speakers (see program) with diverse expertise from medicine, biology, physics and engineering who all made significant contributions in the last decades in deciphering the complex interactions between blood and tissues. The BTI particularly encouraged interactions between participants thanks to dedicated poster presentations, and social events.

Presentation video

Download the Conference Program :

PROGRAM (.PDF)

Manouk Abkarian1, Simon Mendez2, Franck Nicoud2

1 Centre de Biochimie Structurale, CNRS UMR 5048, INSERM UMR 1054, University of Montpellier, 34090 Montpellier, France

2 Institut Montpelliérain Alexander Grothendieck, CNRS, University of Montpellier, 34095 Montpellier, France

The Second International School on HemoPhysics (HemPhys2) was held in Montpellier, France, from 5 October to 8 October 2021. The theme of this second edition was Networks. This document summarizes the salient aspects of HemPhys2.

General presentation

The 2nd International School on HemoPhysics (https://hemphys2.sciencesconf.org) took place at the Maison des Sciences de l’Homme MSH Sud in Montpellier, France, 5-8 October, 2021. It was dedicated to Networks. Lectures were  given by highly renowned researchers of the field, with a target audience of PhD students, Researchers and Engineers. The addressed topics included microcirculation physiology and organization, angiogenesis, flows in networks, microvascular bioengineering, blood flow imaging, pathological blood flow, among others. In addition to the lectures, poster sessions were organized so that the audience can discuss their research and benefit from the expertise of the lecturers. Figure 1 shows a picture of the participants at the MSH Sud.

The following lecturers were invited:

  • P. Bagchi (Rutgers University)
  • P. Connes (University of Lyon)
  • V. Fleury (CNRS Paris)
  • E. Katifori (University of Pennsylvennia)
  • E. Jones (KU Leuven)
  • B. Levy (INSERM Paris)
  • A. Molina P\’erez (Institute of Advanced Social Studies, Spanish National Research Council)
  • A. Scherberich (University Hospital Basel)
  • M. Tanter (INSERM, Paris)

Lectures

10 lectures were given during HemPhys2, with the corresponding keywords:

  • Levy. Physiology of vascular networks (part 1 and part 2): functional anatomy; diffusion characteristics; anomalies in situations of cardiovascular risks. Microcirculation in hypertension.
  • Katifori. Modeling transport in complex vascular networks: setting up and solving the equations for flow in complex hierarchical networks; optimization principles for the network architecture; modeling self-organization and adaptation in vascular networks; the mathematics of pulsatile flow.
  • Jones. Morphogenesis of vessels and vascular network. The point of view of the biologist: Basic principles of vasculogenesis and angioenesis; mechanosensation from a cellular point of view; vascular remodelling and adaptation to flow.
  • Fleury. Morphogenesis of vessels and vascular network. The point of view of the physicist: Vascular morphogenesis; imaging; dynamics; scaling; Monte-Carlo simulation.
  • Bagchi. Blood circulation in microvascular networks 1: blood as a suspension of red blood cells; Blood flow in a network; plasma skimming; cell migration; Fahraeus effect; Fahraeus-Lindqvist effect.
  • Tanter. Functional imaging of the micro vascular flow in vivo using functional Ultrasound and Ultrasound Localization Microscopy: microscopy; neuroimaging; cardiovascular imaging; ultrasound; neurovascular coupling.
  • Bagchi. Blood circulation in microvascular networks 2: Direct simulation of blood cell flow in complex microvascular networks; cell partitioning; development of cell-free layer; wall shear stress; cell deformability.
  • Molina P\’erez. The role of the cessation of blood circulation in the determination of death: Blood circulation as a criterion of death; Spontaneous v. artificially supported blood circulation; Circulatory death v. brain death; Irreversible v. permanent cessation of the circulatory function; The concept of biological function; Ethical considerations.
  • Scherberich. Engineering microvasculature for regenerative medicine: Basic principles of tissue engineering and need for vascularization; Adipose-derived cells; Engineering of pre-vascularized tissues (bone, skin, cardiac patches); Stimulation of angiogenesis (cell and gene therapy, developmental engineering); Prefabrication of vascularized bone and clinical applications
  • Connes. Pathological blood circulation: the example of sickle cell anemia: sickle cell disease; blood rheology; vascular function; inflammation; eryptosis.

Participants

53 participants (24 women, 29 men) from 11 countries were registered to HemPhys2. 30 of the participants were either a PhD candidate or a postdoc.

Participants were invited to present a poster during the whole school. 17 posters were presented:

  1. Allais, M.-C. Audry, C. Boisson, C. Renoux, P. Connes, A. Lavoignat, S. Picot, M. Faivre: A study of red blood cell deformability using microfluidic constrictions
  2. Fenech, V. Girod, V. Claveria, S. Meance, M. Abkarian, B. Charlot: Microfluidic blood vasculature replicas using backside lithography
  3. Zukowski, S. Song, G. Balavoine, C. Ruta, S. Douady, P. Szymczak, A. JM Cornelissen: Reconnections in morphogenesis of the gastrovascular canal network of the jellyfish, Aurelia aurita
  4. Enjalbert, D. Hardman, T. Krüger, and M. O. Bernabeu: Impact of vessel compression on red blood cell partitioning at a downstream bifurcation
  5. Giannetti, E. Genot, B. Charlot, C. Benistant and M. Abkarian: The Onset of Deep Vein Thrombosis (DVT) on-a-chip:The coupling effect of stretch and shear stresses on endothelial cells
  6. Hatem, G. Bouyer, L. Pérès, and S. Egée: The hydration state of red blood cells as an important parameter of erythrocytic functions in circulating conditions
  7. Julien, M. Paques, J.-M. Fullana: 1D Modeling of the Microvascular Network of the Retina
  8. V. Le, S. Samadder, V. Claveria, L. Lanotte, B. Charlot, JF. Brun, J.B. Fiche, M. Fenech and M. Abkarian: Transport in Blood Microcirculation
  9. Murciano, M. G. Rotordam, N. Becker, N. Fertig, L. Kaestner: Automated patch clamp (APC) assay development for the study of ion channels in red blood cells (RBCs)
  10. Pastor Alonso, M. Quintard, F. Boyer, Y. Davit, S. Lorthois: 3D – 1D coupling model applied to molecular transport in the brain microcirculation
  11. Poulain-Zarcos, L. Bergougnoux, F. Blanc et E. Franceschini: Ultrasound for measuring the microstructure of dense suspensions
  12. Rashidi, G. Simionato, A. Darras, T. John, L. Kaestner, M. Laschke, M. Menger, C. Wagner: In-vivo influence of lingering on the partitioning of Red Blood Cell in micro-circulation
  13. Seed, I. Chernyavsky, T. Krüger, and M. Bernabeu: How does the 3D geometry of fetal microvaculature in the placenta affect function and development?
  14. Stathoulopoulos, A. Passos, S. Balabani: Microscale RBC flows in complex domains
  15. Tupin, A. Lam and J. van Batenburg-Sherwood: Continuum microhaemodynamics: experimental and computational approaches
  16. Wrzos, S. Zukowski, K. Rojek, M. Bogdan, J. Guzowski, M. Lisicki, P. Szymczak: Analysis of the capillary plexus formation in a microfluidic cell culture system
  17. Zukowski, P. Morawiecki, H. Seybold, P. Szymczak: Backward evolution of spatial network

Conclusion

In spite of the context of the COVID-19 pandemic, HemPhys2 could be organized as an in-person event. The organizers would like to stress the commitments of the lecturers and the enthusiasm of the participants. On the strength of the success of HemPhys2, the organizers are preparing HemPhys3, which should take place in 2023.

Vidéos

Lecture 1.1: B. Levy (INSERM Paris, France). Physiology of vascular networks (part 1)
Keywords: functional anatomy, diffusion characteristics, anomalies in situations of cardiovascular risks. Microcirculation in hypertension.

Lecture 1.2: B. Levy (INSERM Paris, France). Physiology of vascular networks (part 2)
Keywords: functional anatomy, diffusion characteristics, anomalies in situations of cardiovascular risks. Microcirculation in hypertension.

3-Morphogenisis_of_vessels_and_vascular_networks.The_point_of_view_of_the_biologist.mov
Keywords: Basic principles of vasculogenesis and angioenesis; mechanosensation from a cellular point of view; vascular remodelling and adaptation to flow.

Lecture 4: V. Fleury (CNRS Paris, France). (Morphogenesis of vessels and vascular network. The point of view of the physicist)
Keywords: Vascular morphogenesis, imaging, dynamics, scaling, Monte-Carlo simulation.

Lecture 5: P. Bagchi (Rutgers University, USA). Blood circulation in microvascular networks 1
Keywords: Direct simulation of blood cell flow in complex microvascular networks; cell partitioning; development of cell-free layer; wall shear stress; cell deformability.

Lecture 6: M. Tanter (INSERM Paris, France). Functional imaging of the micro vascular flow in vivo using functional Ultrasound and Ultrasound Localization Microscopy

Lecture 7: P. Bagchi (Rutgers University, USA). Blood circulation in microvascular networks 2